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KMID : 0882419770200010001
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Korean Journal of Medicine
1977 Volume.20 No. 1 p.1 ~ p.5
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Hageman Factor and Complement
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Kim Zae-Zeung
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Abstract
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The human blood plasma contains numerous different protein fractions and polypeptide chains which are electrically charged and biologically active in the normal state, these proteins present as inactive precursors. The activation and inactivation of such proteins are delicately balanced to maintain normal homeostasis.
Once abnormal factors are encountered, these precursors are activated to initiate a host defense mechanism. However, the end result of these biological activations is not only of beneficial effect (preventing the host from diseases), but also a harmful effect to the host (producing the disease).
Furthermore, there are inter-relationships between certain biological proteins. Hageman factor and complement are one of such plasma protein enzyme systems.
The purpose of this paper is to summarize and systematize this complex system.
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